Why Antidepressants Are So Slow to Act — New information about “lipid rafts.”

Millions of Americans are prescribed antidepressants each year, yet it typically takes weeks for patients to feel any effects. Researchers could never explain the peculiarity, but new work published in July offers a clue.

The study, from researchers at University of Illinois at Chicago, examined rat brain cells and focused on lipid rafts — an area of the cell membrane that specializes in organizing important molecules. Previous studies showed that, in depressed patients, lipid rafts sequester a protein involved in cell signaling, called GαS, keeping it from doing its job.

Read the full Jan/Feb 2016 feature at Discover Magazine